Mayo CMML Prognostic Model Calculator

Mayo CMML Prognostic Model Calculator

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FAQs

What is the CMML specific prognostic scoring system? The CMML-specific prognostic scoring system typically includes factors like age, blood cell counts, and cytogenetic abnormalities to assess the prognosis of CMML patients.

What is the life expectancy of a person with CMML? The life expectancy for CMML can vary widely depending on factors such as the subtype of CMML, overall health, and response to treatment. On average, individuals with CMML may have a life expectancy of several years after diagnosis.

How fast does CMML progress? The progression rate of CMML can vary. Some individuals may experience slow disease progression, while others may have a more aggressive course. It depends on the specific subtype and individual characteristics.

Can CMML go into remission? Yes, CMML can go into remission with treatment, but the likelihood of achieving remission and the duration of remission can vary.

What are the markers for CMML? Markers for CMML often include specific blood cell counts, such as elevated monocyte counts, and cytogenetic abnormalities.

What are the CD markers for CMML? Common CD markers associated with CMML include CD13, CD14, CD33, CD34, and CD117.

What causes death in CMML? Death in CMML can result from complications related to bone marrow failure, infections, and progression to acute leukemia.

Is CMML aggressive? CMML can be either indolent (slow-growing) or more aggressive, depending on the subtype and individual factors.

Can you beat CMML? With appropriate treatment and management, some individuals with CMML can achieve remission and have a good quality of life. However, CMML is a chronic condition, and long-term outcomes vary.

How does CMML make you feel? CMML symptoms can vary but may include fatigue, weakness, recurrent infections, and other symptoms related to low blood cell counts.

Is CMML painful? CMML itself is not typically associated with significant pain, but complications or related conditions may cause discomfort.

Does CMML affect the brain? CMML primarily affects the bone marrow and blood cells. It does not directly affect the brain, but complications or treatments may have neurological effects.

What is the survival rate for CMML leukemia by age? Survival rates can vary significantly by age and other factors. Generally, older individuals may have a lower survival rate due to comorbidities.

How rare is CMML leukemia? CMML is considered a rare subtype of leukemia, accounting for a small percentage of all leukemia cases.

Does CMML have stages? CMML is often classified into two main subtypes: CMML-1 and CMML-2, based on the percentage of blasts (immature cells) in the bone marrow.

What is the WBC count in CMML? The white blood cell count (WBC) can vary in CMML but is often elevated, particularly in cases with more aggressive features.

What is the first line of treatment for CMML? Treatment for CMML may include supportive care, medications to manage symptoms, and, in some cases, stem cell transplantation.

How high are monocytes in CMML? CMML is characterized by an elevated monocyte count, often above 1 x 10^9/L.

What does blood work look like with CMML? Blood work in CMML may show abnormalities in white blood cell, red blood cell, and platelet counts, as well as the presence of abnormal cells in the blood.

What is Type 2 CMML leukemia? Type 2 CMML (CMML-2) is a subtype with a higher percentage of blasts (5-19%) in the bone marrow compared to CMML-1.

What are the criteria for CMML diagnosis? Diagnosis of CMML typically involves assessing blood cell counts, bone marrow biopsy, cytogenetic analysis, and clinical criteria.

What are the symptoms of end stage leukemia? End-stage leukemia may involve severe infections, bleeding, extreme fatigue, organ failure, and a decline in overall health.

Which is worse MDS or CMML? Both MDS (Myelodysplastic Syndromes) and CMML have variable outcomes. CMML is considered a subtype of MDS and can have different prognostic factors.

Can CMML cause heart problems? CMML itself may not directly cause heart problems, but complications or treatments can impact cardiovascular health.

Can CMML affect your eyes? CMML typically does not directly affect the eyes, but certain complications or medications may have ocular side effects.

Can CMML spread to other organs? CMML primarily affects the bone marrow and blood cells. It does not spread to other organs like solid tumors.

What is a low risk CMML? Low-risk CMML refers to cases with less aggressive features, including lower blast counts and fewer complications.

Is CMML hereditary? CMML is not typically inherited but can rarely have a genetic component.

Can CMML be misdiagnosed? Like many medical conditions, CMML can be misdiagnosed, especially in its early stages, due to its varied presentation.

Can CMML cause back pain? Back pain is not a common symptom of CMML, but it may be related to complications or other underlying conditions.

What is the rarest type of leukemia? Among leukemia subtypes, CMML is considered relatively rare. However, other rare subtypes exist.

How do you know if leukemia has spread to the brain? Leukemia typically does not spread to the brain like metastatic cancer. Symptoms related to the central nervous system may indicate involvement.

Is CMML an autoimmune disease? No, CMML is not an autoimmune disease. It is a hematologic malignancy affecting the bone marrow and blood cells.

Does leukemia affect your memory? Leukemia itself does not directly affect memory, but it can cause fatigue and cognitive changes due to the disease and treatments.

Can you live 20 years with chronic myeloid leukemia? With appropriate treatment, many individuals with chronic myeloid leukemia (CML) can achieve long-term remission and potentially live for decades.

What is the prognosis for leukemia at 70? Prognosis for leukemia at age 70 or older can vary, but it may be influenced by overall health and treatment options.

Can chronic leukemia live 20 years? Some individuals with chronic forms of leukemia, such as chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML), can live for 20 years or more with proper management.

What happens if you don’t treat CMML? Untreated CMML can lead to complications, such as anemia, infections, and progression to acute leukemia, which can be life-threatening.

What level of WBC is alarming? A very high or very low white blood cell count can be alarming, but the specific threshold depends on individual factors and context.

What is the highest WBC in leukemia? The white blood cell count can become extremely elevated in some cases of acute leukemia, reaching levels in the hundreds of thousands per microliter.

What is the highest white blood cell count in leukemia? The highest white blood cell count in leukemia can vary, but it can reach extremely high levels, often above 100,000 per microliter, in some acute leukemia cases.

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